The YjbH adaptor protein enhances proteolysis of the transcriptional 1 regulator Spx in Staphylococcus aureus 2 3
نویسندگان
چکیده
regulator Spx in Staphylococcus aureus 2 3 Jakob Engman, Annika Rogstam , Dorte Frees, Hanne Ingmer and Claes von Wachenfeldt 4 5 Department of Biology, Lund University, Sölvegatan 35, SE-223 62 Lund, Sweden 6 7 Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, 8 Frederiksberg C, Denmark. 9 10 11 *Corresponding author: 12 Phone: +46 46 222 3456 13 Fax: +46 46 222 4113 14 Email: [email protected] 15 16 Copyright © 2011, American Society for Microbiology. All Rights Reserved. J. Bacteriol. doi:10.1128/JB.06414-11 JB Accepts, published online ahead of print on 22 December 2011
منابع مشابه
The YjbH adaptor protein enhances proteolysis of the transcriptional regulator Spx in Staphylococcus aureus.
Spx is a global regulator that is widespread among the low-G+C-content gram-positive bacteria. Spx has been extensively studied in Bacillus subtilis, where it acts as an activator and a repressor of transcription in response to disulfide stress. Under nonstress conditions, Spx is rapidly degraded by the ClpXP protease. This degradation is enhanced by the YjbH adaptor protein. Upon disulfide str...
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The global transcriptional regulator Spx of Bacillus subtilis is controlled at several levels of the gene expression process. It is maintained at low concentrations during unperturbed growth by the ATP-dependent protease ClpXP. Under disulfide stress, Spx concentration increases due in part to a reduction in ClpXP-catalyzed proteolysis. Recent studies of Larsson and coworkers (Mol. Microbiol. 6...
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